In adults with high blood pressure, abrupt cessation of clonidine hydrochloride extended-release solution treatment in the 0.2 to 0.6 mg/day range led to reports of headache, tachycardia, queasiness, flushing, warm feeling, short lightheadedness, tightness in breast, and anxiety.
In grownups with hypertension, unexpected cessation of therapy with immediate-release clonidine has, in many cases, resulted in symptoms such as anxiety, frustration, agitation, and also frustration come with or followed by a quick surge in blood tension and also elevated catecholamine focus in the plasma.
In individuals which have actually established local call sensitization to clonidine transdermal system, continuation of clonidine transdermal system or substitution of dental clonidine hydrochloride therapy might be linked with the development of a generalized skin rash.
In individuals which create an allergic reaction from clonidine transdermal system, replacement of oral clonidine hydrochloride might likewise bring about a sensitive response (including generalized angioedema, rash, or urticaria).
The sympatholytic action of clonidine could worsen sinus node disorder and atrioventricular (AV) block, especially in people taking other sympatholytic medications. There have been post-marketing records of patients with conduction abnormalities and/or taking other sympatholytic medicines that developed serious bradycardia requiring IV atropine, IV isoproterenol, and also short-lived heart pacing while taking clonidine. Uptitrate clonidine hydrochloride extended-release tablets slowly and also keep an eye on vital indicators often in individuals with heart transmission irregularities or individuals concomitantly treated with other sympatholytic medicines.